Marcel Bruchez, PhD
Professor of Chemistry
Professor of Biological Sciences
Professor of Computational Biology and Biomedical Engineering (By Courtesy)
Carnegie Mellon University
Pittsburgh, PA 15213
As President, my experience and interests position me well to look for opportunities to expand the impact of the society in new measurement areas, to broaden our membership and to enhance our professional development offerings. I look forward to leveraging our unique society strengths to build an increased footprint in emerging quantitative cellular analysis methods, and to position ISAC, its meetings and its journals, as the standard-setter and the premier venues for single-cell, data-driven biological research.
I am a tenured Full Professor in the Chemistry and Biological Sciences departments at Carnegie Mellon University, whose work is focused on developing new methods for analytical cytometry measurements in living cells using innovative fluorescent labels. I direct the Molecular Biosensor and Imaging Center at CMU, which performs research, and provides core-services to the Carnegie Mellon University research community in biological microscopy and flow cytometry. I am an inventor of the quantum dot technology that extended the multiplexing capabilities of flow cytometers significantly by providing many spectrally resolvable channels that work with violet laser excitation, and founded Quantum Dot Corporation, the company that successfully developed Qdot probes useful in cytometry prior to its acquisition by Invitrogen/Life Technologies. My work in this area was awarded the Rank Prize for Optoelectronics in 2006. I have been an active member of ISAC throughout my career, serving on the Program Committee (2010, 2011, 2014, 2016) and Organizing Committes (2012, 2018) for many past meetings, and serving as Conference Chair for the record-setting Cyto2017 meeting in Boston, MA.
I believe that ISAC serves an essential function in the biological and biomedical research community, providing scientific and professional development opportunities for both academic researchers and shared resource directors, an increasingly important connection in the modern scientific enterprise. As President of the society, I would aim to expand the training and standard-setting mission, to include statistical analysis of large data sets, expanding beyond flow-based methods to include multiparameter, cellular measurements that encompass sequencing, imaging and flow-based methodologies. As recent Cyto meetings have shown, methods developed for analysis of high-dimensionality single-cell flow cytometry data can be readily applied in diverse situations, leveraging the expertise of the society into a range of modern and emerging research approaches. In addition, I strongly support the open-data initiatives and transparent and objective testing of analysis methodologies that were pioneered by ISAC (e.g. FCS standards, FLOWCap, and FLOWrepository). We organized the first Image Analysis Challenge at Cyto2017. It is clear that modern biological research is advanced by skilled and knowledgeable users operating state-of-the-art equipment, using best-practice methods and experimental design. ISAC is uniquely positioned to serve this growing need.
As an innovator and academic researcher, I strongly support the efforts of ISAC to reach out to the entrepreneur, startup and commercial communities whose efforts are essential to increasing the impact of new technological innovations beyond the original pioneer lab. Programs like CytoInnovation have expanded the membership and increased the participation of young scholars and brought diverse perspectives to our society. These should continue to develop and expand.