A high-throughput acoustic cell sorter
“A high-throughput acoustic cell sorter”, L. Ren, Y. Chen, P. Li, Z. Mao, P-H. Huang, J. Rufo, F. Guo, L. Wang, J. McCoy, S. Levine and T. Huang. Lab on a Chip, 2015, 15, 3870.
Abbreviated Summary: A high-throughput cell sorting method based on standing surface acoustic waves (SSAWs) is reported. A pair of focused interdigital transducers (FIDTs) were used to generate SSAW with high resolution and high energy efficiency. Sorting throughput improved significantly from conventional acoustic-based cell sorting methods. Sorting 10 μm polystyrene particles with a minimum actuation time of 72 μs was demonstrated. This translates to a potential sorting rate of more than 13800 events per second. Without using a cell-detection unit, they were able to demonstrate an actual sorting throughput of 3300 events per second.