Orla Maguire

Senior Flow Cytometry Specialist
Roswell Park Cancer Institute
Buffalo, NY, USA

Education Post-doctoral fellow, Roswell Park Cancer Institute, Buffalo, NY Ph.D. Biomedical Sciences, Ulster University, Northern Ireland, UK, 2008 B.Sc. (HONS) Biomedical Sciences, Ulster University, Northern Ireland, UK, 2004

Scientific Interest and Avenues for Collaboration My research interests are focused on developing applications of imaging flow cytometry (IFC), with special attention to cell signaling. My recent focus has been in the effect of chemotherapies on transcription factor pathways in immunophenotypically-defined T cell populations. I am also interested in measuring cellular communication via exosome signaling using IFC.

Participation / Support of ISAC ISAC member since 2011 Reviewer for Cytometry Part A since 2017 CYTO Program committee member since 2015 CYTO 2011 Poster: Time kinetic study of p65 phosphorylation events in relation to NF-κB nuclear translocation CYTO 2013 Oral presentation: Image Cytometry-Based Detection of Aneuploidy by FISH-IS CYTO 2013 Poster: Simultaneous assessment of CMV specificity and functional response in CD8+ T cells from bone marrow transplant recipients CYTO 2014 Poster: NF-κB, NFAT1 and ERK1/2 signaling kinetics following allogeneic hematopoietic cell transplantation CYTO 2016 Poster: Ovarian carcinoma ascites-derived extracellular vesicles inhibit NFAT signaling in antigen-specific T-cells CYTO 2017 Oral presentation: MHC multimers induce a functionally relevant activation of the NFAT pathway.

Website
http://www.rpciflow.org
http://www.sciencemag.org/custom-publishing/webinars/monitoring-immune-function-imaging-flow-cytometry