Sara De Biasi
Sara De Biasi
Education Ph.D., University of Modena and Reggio Emilia, Italy (supervisor: Prof. Andrea Cossarizza) Post-doctoral fellow, Department of Surgery, Medicine, Odontoiatrics and Morphological Sciences (supervisor: Prof. Andrea Cossarizza).
Scientific Interest and Avenues for Collaboration I am interested in the dynamics of T cell homeostasis and functions in conditions of acquired immunodeficiencies, with a special focus on HIV infection and solid organ transplantation and related therapies. More recently, my work focused on multiple sclerosis as a model to study autoimmunity. In particular, I am investigating the role of innate-like T cells (iNKT cells), rare cell populations among peripheral blood mononuclear cells. In addition, I took advantage of the experience acquired in the field of rare events detection such as iNKT cells to study circulating endothelial cells (CEC), their precursor (EPC) in different type of cancers.
Participation/Support of ISAC CYTO 2017: T cells from patients with primary progressive form of Multiple Sclerosis display altered metabolism and mitochondrial functionality; Patients with severe sepsis display low levels of circulating Mucosal Associated Invariant T cells; High CD4:CD8 ratio and length of treatment independently correlate to the HIV-DNA intracellular content in different subsets of CD4+ T cells from virologically suppressed HIV+ patients; LonP1 differently modulates mitochondrial function and bioenergetics of primary versus metastatic colon cancer cells (Poster presentation). CYTO 2016: High Level of Activation and Altered Mitochondrial Functionality in T Cells from Patients with Progressive Forms of Multiple Sclerosis (Oral presentation). CYTO 2015: Polyfunctional Response of Invariant Natural Killer T Cells in Patients Affected by Multiple Sclerosis Displays Th-1 and Th-17 Profiles (Outstanding poster Award). Inhibition of Lon protease by triterpenoids alters mitochondria and is associated to cell death in human cancer cells (Poster prensentation). iNKT Cells and Their Subpopulations Are Not Restored in HIV+ Patients with Low CD4/CD8 ratio after Prolonged Effective Therapy, and Display a Pronounced Th-1 and Th-17 Pro-inflammatory Profile (Poster prensentation). CYTO 2014: Fine tuning of Treg and iNKT cells after treatment with Fingolimod in Multiple Sclerosis patients (Oral presentation). Principal Component Analysis allows to cluster patients with Multiple Sclerosis on the basis of different subsets of CD8+ and iNKT cells (Oral presentation). CYTO 2013: Complex changes in invariant Natural Killer T (iNKT) cells in patients with different clinical forms and treatments of Multiple Sclerosis (Oral presentation). CYTO 2012: Evidences for Autophagy in SW872 Adipocytic Cells Treated with Atazanavir (Poster presentation).